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(Stroke. 1970;1:248.)
© 1970 American Heart Association, Inc.

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Experimental Subarachnoid Hemorrhage: A Study for Spasm with the Production of Aneurysms

VANCE C. ROY JR. M.D.¹; THORALF M. SUNDT JR. M.D.²; FRANCIS MURPHEY M.D.³

¹ University of Tennessee, Memphis; Chelsea Naval Hospital, Chelsea, Massachusetts
² Section of Neurological Surgery, and Section of Cerebrovascular Research, Mayo Clinic, Rochester, Minnesota
³ University of Tennessee, Memphis

We have shown the difficulty in producing a reliable model of vasospasm secondary to recurrent subarachnoid hemorrhage from carotid puncture in a squirrel monkey. In this animal, mild systemic hypertension had little or no effect on the clinical status after hemorrhage. The consistent production of a saccular aneurysm on the intracranial arteries was an unexpected result of the arterial puncture and the interruption of the internal elastic membrane. At this time, there is insufficient knowledge regarding the entire subject of vasospasm for correlation with human vessel reaction to injury.

Key Words: arterial trauma • intracranial vasospasm • cerebral angiography • experimental hypertension • laboratory animal