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(Stroke. 1970;1:325.)
© 1970 American Heart Association, Inc.

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The Effect of Isordil and Cyclospasmol on Vascular Spasm Induced in the Basilar Artery of the Cat

M. S. MAHALEY JR. M.D., PH.D.¹ JOHN KAPP M.D., PH.D.¹

¹ Division of Neurosurgery and Anatomy, Duke University Medical Center, Durham, North Carolina, 27706

Vasospasm of the basilar artery of the cat was induced by subarachnoid bleeding and was observed by a transoral approach to the vessel. Intravenous Isordil (2 to 4 mg/kg) given following vasospasm produced vasodilatation with minimal arterial hypotension. Cyclospasmol, administered intravenously after vasospasm or orally prior to vasospasm, was ineffective in relieving or preventing basilar artery spasm.

Key Words: brain spasmolytic drugs