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(Stroke. 1970;1:370.)
© 1970 American Heart Association, Inc.

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Blood Flow in the Central and Peripheral Nervous System of Dogs Using a Particle Distribution Method

THOMAS H. TSCHETTER M.D.¹; ARTHUR C. KLASSEN M.D.¹; JOSEPH A. RESCH M.D.¹; MAURICE W. MEYER PH.D., D.D.S.¹

¹ Departments of Neurology and Physiology, Health Sciences Center, University of Minnesota, Minneapolis, Minnesota, 55455

In this study known activities of ⁸⁵Sr and ¹⁶⁹Yb-labeled microspheres were injected sequentially into the left ventricle of anesthetized dogs. Cardiac output was determined before and after each microsphere injection. Blood flow to brain, brain stem, spinal cord, and sciatic nerve was measured from fractional distribution of the microspheres in the tissue samples. Both blood flow and fractional uptake value tended to be higher for brain and brain stem than for spinal cord or sciatic nerve. Increases in arterial Pa_COCO2 were positively correlated with increases in blood flow to both central and peripheral nervous tissue. Initial trapping of the labeled microspheres seems to have little effect on subsequent flow to the tissue capillary bed. It appears that the particle distribution technique may provide a reasonable estimate of blood flow in central and peripheral nervous tissue of dogs.

Key Words: isotope-labeled microspheres • brain peripheral nerves • spinal cord • brain stem