Stroke, Vol 10, 267-272, Copyright © 1979 by American Heart Association
WA Pulsinelli and JB Brierley
A new model of transient, bilateral hemispheric ischemia in the
unanesthetized rat is described. During ether anesthesia the rat's
vertebral arteries were electrocauterized through the alar foramina of the
first cervical vertebra and reversible clasps placed loosely around the
common carotid arteries. Twenty-four hr later, the awake rats were
restrained and the carotid clasps tightened to produce 4-vessel occlusion.
The carotid clasps were removed after 10, 20 or 30 min of 4- vessel
occlusion and the animals killed by perfusion fixation 72 hr later. Rats
which convulsed during the ischemic or post-ischemic period were excluded
from further study. All rats subjected to 20 or 30 min of 4-vessel
occlusion demonstrated ischemic neuronal damage. The H1 and paramedian
hippocampus, striatum and layers 3, 5 and 6 of the posterior neocortex were
the regions most frequently damaged. The advantages of this model are the
ease of preparation of large numbers of animals, a high rate of predictable
ischemic neuronal damage, a low incidence of seizures and the absence of
anesthesia.
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A new model of bilateral hemispheric ischemia in the unanesthetized rat
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