This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ackerman, R. H. Articles by Taveras, J. M. Search for Related Content PubMed PubMed Citation Articles by Ackerman, R. H. Articles by Taveras, J. M.

Stroke, Vol 11, 45-49, Copyright © 1980 by American Heart Association

ARTICLES

Positron imaging of cerebral blood flow during continuous inhalation of C15O2

RH Ackerman, R Subramanyam, JA Correia, NM Alpert and JM Taveras

This investigation tests the hypothesis that the normal cerebral image obtained non-invasively during continuous inhalation of C15O2 is related to cerebral blood flow. Trace amounts of CO2 labeled with the positron-emitting radionuclide 15O were administered to 4 normal subjects at normo- and hypocapnia and to 2 of these subjects at hypercapnia. Hypocapnia typically caused a marked decrease in cerebral 15O activity, and hypercapnia a small increase in activity. The relative difference in the change in count rate in response to hypo- and hypercapnia is what one would expect if the activity represented bloow flow, according to a mathematical model which assumes the 15O label enters the brain as water of perfusion. The findings in this study suggest that the normal cerebral image obtained during continuous inhalation of C15O2 is related to cerebral blood flow, but in a non- linear fashion, and that the technique would be more sensitive to ischemic events than to hyperemic phenomena.

This article has been cited by other articles:

				M. E. PHELPS, H. R. SCHELBERT, and J. C. MAZZIOTTA Positron Computed Tomography for Studies of Myocardial and Cerebral Function Ann Intern Med, March 1, 1983; 98(3): 339 - 359. [Abstract] [PDF]

				R. H. Ackerman, J. A. Correia, N. M. Alpert, J.-C. Baron, A. Gouliamos, J. C. Grotta, G. L. Brownell, and J. M. Taveras Positron Imaging in Ischemic Stroke Disease Using Compounds Labeled With Oxygen 15: Initial Results of Clinicophysiologic Correlations Arch Neurol, September 1, 1981; 38(9): 537 - 543. [Abstract] [PDF]