Stroke, Vol 12, 47-53, Copyright © 1981 by American Heart Association
I Podreka, WD Heiss and T Brucke
A scintillation camera connected to a dedicated computer system was
employed for atraumatic CBF measurements in 43 patients after intravenous
injection of 35 to 55 mCi 133Xe in saline solution. To validate this method
results were compared to flow values in the same patients measured after
intracarotid Xe injection. While the correlation between i.c. and i.v.
values was not satisfactory when a high resolution collimator was used, a
high sensitivity collimator improved count rates and yielded CBF values
after i.v. in agreement with those from i.c. studies. For mean hemispheric
flow, the correlation coefficient between the methods was 0.93 and the
standard deviation of the i.v. value for a given i.c. value was 2.93. The
correlation coefficients for 13 regions were between 0.55 and 0.85. These
correlation coefficients are comparable to those obtained with
multidetector equipment. Ischemic regions could be accurately detected, and
the flow values in these areas were significantly related (r = 0.81).
Values in 6 healthy volunteers were in the normal range reported by other
investigators. One disadvantage of the camera is that measurements are
restricted to one hemisphere, but selection of recording areas is not
limited to the position of single probes and may be changed during analysis
of the data permitting analysis of flow in irregularly-shaped,
pathologically-perfused regions. The results indicate that the
scintillation camera is a useful tool for clinical rCBF studies.
ARTICLES
Atraumatic CBF measurement with the scintillation camera. Comparison with intracarotid rCBF values