This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Murai, A. Articles by Kameyama, M. Search for Related Content PubMed PubMed Citation Articles by Murai, A. Articles by Kameyama, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CHOLESTEROL Medline Plus Health Information Transient Ischemic Attack

Stroke, Vol 12, 167-172, Copyright © 1981 by American Heart Association

ARTICLES

Lipoprotein abnormalities in the pathogenesis of cerebral infarction and transient ischemic attack

A Murai, T Tanaka, T Miyahara and M Kameyama

HDL-cholesterol levels were determined by a heparin-Ca precipitation method in 89 survivors of cerebral infarction (CI) (75 males, 14 females) and 14 patients with transient ischemic attacks (TIA) (8 males, 6 females). The mean values of HDL-cholesterol concentration and HDL:LDL-cholesterol ratio for both sexes of CI patients were significantly lower than those of the healthy controls (37 males, 14 females). These values for CI patients were significantly lower than in patients with various diseases excluding cardiovascular disease, hepatic disease, hyperlipidemia, diabetes mellitus and degenerative disorders of the nervous system (46 males, 43 females). In patients with TIA, these differences were statistically significant only for men. Based on the patient's history, clinical signs and symptoms and the findings of computerized tomography and 4-vessel angiography, male CI patients were divided into 2 sub-groups, CI believed to be in the distribution of a perforating artery and CI in the distribution of a cortical artery; it was found that the HDL-cholesterol level and HDL:LDL-cholesterol ratio were significantly lower in the cortical artery group than in the perforating artery group, suggesting that these lipoprotein abnormalities may play a part in the pathogenesis of CI, particularly of the cortical artery area infarction.

This article has been cited by other articles:

				R. L. Sacco, R. T. Benson, D. E. Kargman, B. Boden-Albala, C. Tuck, I-F. Lin, J. F. Cheng, M. C. Paik, S. Shea, and L. Berglund High-Density Lipoprotein Cholesterol and Ischemic Stroke in the Elderly: The Northern Manhattan Stroke Study JAMA, June 6, 2001; 285(21): 2729 - 2735. [Abstract] [Full Text] [PDF]

				S. L. M. Bakker, F.-E. de Leeuw, P. J. Koudstaal, A. Hofman, and M. M. B. Breteler Cerebral CO2 reactivity, cholesterol, and high-density lipoprotein cholesterol in the elderly Neurology, February 22, 2000; 54(4): 987 - 989. [Abstract] [Full Text] [PDF]

				F. Guerrero-Romero and M. Rodriguez-Moran Proteinuria Is an Independent Risk Factor for Ischemic Stroke in Non–Insulin-Dependent Diabetes Mellitus Stroke, September 1, 1999; 30(9): 1787 - 1791. [Abstract] [Full Text] [PDF]

				H. KIMURA, F. GEJYO, T. YAMAGUCHI, S. SUZUKI, T. IMURA, R. MIYAZAKI, and M. ARAKAWA A Cholesteryl Ester Transfer Protein Gene Mutation and Vascular Disease in Dialysis Patients J. Am. Soc. Nephrol., February 1, 1999; 10(2): 294 - 299. [Abstract] [Full Text]

				M. Catalano, E. Perilli, G. Carzaniga, G. Scandale, and M. Carotta Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients Clinical and Applied Thrombosis/Hemostasis, April 1, 1997; 3(2): 104 - 109. [Abstract] [PDF]

				H. Fukuda and M. Kitani Cigarette Smoking Is Correlated With the Periventricular Hyperintensity Grade on Brain Magnetic Resonance Imaging Stroke, April 1, 1996; 27(4): 645 - 649. [Abstract] [Full Text]

				S. Lehto, T. Ronnemaa, K. Pyorala, and M. Laakso Predictors of Stroke in Middle-Aged Patients With Non–Insulin-Dependent Diabetes Stroke, January 1, 1996; 27(1): 63 - 68. [Abstract] [Full Text]

				E Lindenstrom, G Boysen, and J Nyboe Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen city heart study BMJ, July 2, 1994; 309(6946): 11 - 15. [Abstract] [Full Text]

				C. F. Terrence and G. R. Rao Triglycerides as a Risk Factor in Extracranial Atherosclerotic Cerebrovascular Disease Angiology, July 1, 1983; 34(7): 452 - 460. [Abstract] [PDF]