Stroke, Vol 12, 864-868, Copyright © 1981 by American Heart Association
N Wiernsperger, AL Sylvia and FF Jobsis
Differential near infrared spectrophotometry was used to monitor sequential
in vivo alterations in cerebral hemoglobin saturation, blood volume, and
cytochrome c oxidase reduction/oxidation responses during and after a
period of incomplete transient ischemia (acute, reversible common carotid
artery occlusion). In this study the rat brain was monitored non-invasively
in the intact skull by transillumination. The data show that an increase in
cerebral deoxygenation of hemoglobin, which occurs simultaneously with a
decrease in blood volume subsequent to carotid ligation, acts as a
compensatory mechanism to assist in maintaining aerobic energy metabolism.
The observations also demonstrate that in this species the effects of
bilateral carotid occlusion on the cerebrovascular parameters are not
necessarily irrevocable. The intramitochondrial metabolic alterations, as
evaluated by cytochrome c oxidase redox transitions, are reversible as long
as the systemic arterial blood pressure does not fall below a value of
approximately 40 mm Hg. These data suggest that possibility of being able
to use a critical reduction level of cytochrome c oxidase as an early
indication of ischemia-induced cerebral metabolic dysfunction prior to
major changes in high energy stores.
ARTICLES
Incomplete transient ischemia: a non-destructive evaluation of in vivo cerebral metabolism and hemodynamics in rat brain
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