This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Little, J. R. Articles by Stowe, N. T. Search for Related Content PubMed PubMed Citation Articles by Little, J. R. Articles by Stowe, N. T.

Stroke, Vol 13, 302-307, Copyright © 1982 by American Heart Association

ARTICLES

Treatment of acute focal cerebral ischemia with propranolol

JR Little, JP Latchaw Jr, RM Slugg, RP Lesser and NT Stowe

Propranolol has been found to have a protective effect in experimental myocardial ischemia. Protection of ischemic kidneys was subsequently demonstrated following treatment with propranolol and its weaker beta blocking isomer, d-propranolol. The objective of the present investigation was to study the effects of propranolol (i.e., racemic d,1 mixture) and d-propranolol upon regional cerebral blood flow (rCBF) and early ischemic changes following experimental middle cerebral artery (MCA) occlusion. Thirty adult cats, lightly anesthetized with ketamine hydrochloride, underwent 3 hours or right MCA occlusion. Ten cats were untreated. Ten cats were given a continuous infusion of propranolol (1 mg/kg/hr) for 4 hours beginning 1 hour before MCA occlusion and a 4 mg/kg bolus immediately before occlusion. Ten cats were given a continuous infusion of d-propranolol (0.5 mg/kg/hr) for 4 hours beginning 1 hour before MCA occlusion and a 2 mg/kg bolus immediately before occlusion. The therapeutic agents were injected directly into the right carotid artery. The rCBF in the right Sylvian region was not significantly different in the 3 groups. EEG changes also were similar. Carbon filling defects were found to be smallest in the d-propranolol-treated group. Light microscopic studies demonstrated a reduction in infarct size in the propranolol and d-propranolol groups. The findings of the investigation indicated that propranolol and d-propranolol do not have a deleterious effect on rCBF after MCA occlusion and suggested that these agents have a protective effect upon ischemic cerebral tissue.

This article has been cited by other articles:

				T. Goyagi, T. Kimura, T. Nishikawa, Y. Tobe, and Y. Masaki {beta}-Adrenoreceptor Antagonists Attenuate Brain Injury After Transient Focal Ischemia in Rats. Anesth. Analg., September 1, 2006; 103(3): 658 - 663. [Abstract] [Full Text] [PDF]