Stroke, Vol 13, 327-333, Copyright © 1982 by American Heart Association
JT Salonen, P Puska, J Tuomilehto and K Homan
The impact of blood pressure, serum cholesterol and triglycerides, and
smoking on the risk of cerebral infarction and other stroke was studied by
a longitudinal design. A random sample of the population aged 35-59 years
in two counties of Eastern Finland was examined in 1972, with a
participation rate of 92 per cent. In subjects (both sexes) standardized
epidemiological measurements on blood pressure, height, weight, and serum
lipids were made and questionnaire data were obtained on smoking. The
cohort was followed for seven years by means of national hospital discharge
and death certificate registers. During the follow-up 77 men and 65 women
had a cerebral stroke. Based on multiple logistic risk function analysis,
age, smoking, blood pressure, and history of previous stroke and diabetes
turned out to be independent predictors of both cerebral infarction and
other strokes in men. Diastolic blood pressure of 100 mm Hg or more was
associated with a 1.9- fold (90% CI = 1.1-3.6) risk of cerebral infarction
in men and 2.5-fold (90% CI = 1.1-5.6) risk in women with no previous
stroke. In men 37% (90% CI = 21-53%) of all cerebral strokes were
attributable to systolic blood pressure of 150 mm Hg or more and 27% (90%
CI = 11-42%) to diastolic blood pressure of 95 mm Hg or more.
ARTICLES
Relation of blood pressure, serum lipids, and smoking to the risk of cerebral stroke. A longitudinal study in Eastern Finland
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