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Stroke. 1983;14:210-213

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Stroke, Vol 14, 210-213, Copyright © 1983 by American Heart Association

ARTICLES

Human pial vascular reactions to intravenous Nimodipine-infusion during EC-IC bypass surgery

LM Auer, RW Oberbauer and HV Schalk

In previous experimental work, the Ca-antagonist Nimodipine had shown a predominantly cerebroarterial dilatory effect. In the present double- blind study of 16 patients, pial arterial and venous reaction was investigated during EC-IC bypass surgery, infusing 1 microgram kg-1min- 1 of Nimodipine intravenously. In pial arteries with resting diameters between 25 and 70 micrometers, a significant 18% dilatation was observed. Results are considered promising for future trials in the treatment and prevention of cerebral ischemia caused by vasoconstriction or vasospasm, especially vasospasm following subarachnoid hemorrhage.




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