Stroke, Vol 14, 256-266, Copyright © 1983 by American Heart Association
S Uematsu, A Yang, TJ Preziosi, R Kouba and TJ Toung
With the use of a new ultrasonic volume flow meter (VFM), over 8000
measurements of common carotid blood flow were made in 120 normal control
subjects and 550 patients with various neurological disease. The accuracy
of the flow meter in measuring blood flow on an experimental model ranged
from 93 to 97%. In normal subjects, common carotid blood flow varies with
age. It increased from newborn to age 20 and gradually decreased
thereafter. In normal healthy subjects, the flow varies within +/- 6.7%
(2SD) at one sitting (intrasession) and +/- 21.2% (2SD) from week to week
(intersession study). Carotid blood flow varies linearly with PaCO2 and
increased markedly in response to endotracheal intubation. In healthy
adults, the flow ratio between the two common carotid arteries is 1.07 +/-
0.052. This ratio increases in patients with transient ischemic attacks to
1.28 +/- 0.23 (p less than 0.05) and in patients with intracranial space
occupying lesions to 1.46 +/- 0.39, (p less than 0.01). In 26 consecutive
cases of carotid endarterectomies, the preoperative common carotid blood
volume flow was 5.1 +/- 1.0 cc/sec. All cases preoperatively had at least
30% stenosis and ranged from 30 to 100% stenosis. The carotid blood volume
was significantly increased post-operatively (p less than 0.001). The
overall accuracy in detecting carotid and cerebral arterial disease is 89%
with sensitivity of 96% and the specificity of 71%. Our clinical experience
indicates that this device is not only a valuable noninvasive diagnostic
tool for evaluation of carotid disease but also appears to be useful in
assessing cerebral blood flow.
ARTICLES
Measurement of carotid blood flow in man and its clinical application
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