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Stroke, Vol 14, 924-928, Copyright © 1983 by American Heart Association
HV Vinters and JJ Gilbert
Ten histologic sections were sampled from similar cortical regions in each
of 84 autopsy brains removed from patients aged 60 to 97 years. The
sections were stained by the Congo-red method and examined under polarized
light for the presence of cortical (parenchymal) cerebral amyloid
angiopathy (CAA). Some degree of CAA was found in 36% of all brains
examined, with a higher proportion of patients affected in each successive
decade of life. Angiopathy was seen most frequently and was of greater
severity in the parietal and occipital gray matter. Overall, it was often a
patchy and asymmetric lesion. There was sparing of subcortical white matter
and the hippocampi. CAA was most severe in cases of Alzheimer's disease,
but occurred in the absence of this condition.
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