Stroke, Vol 14, 964-967, Copyright © 1983 by American Heart Association
M Globus, A Keren, M Eldad, C Granot, D Tzivoni, S Lavy and S Stern
In 31 hypertensive patients the effect of chronic oral administration of
the beta blocking agent propranolol on regional cerebral blood flow (rCBF)
was studied, using the non-invasive 133Xenon inhalation technique. The
results of the measurements were compared to the rCBF obtained in an
age-matched normal control group. Our study shows that during long-term
therapy with low doses of propranolol (less than 120 mg/daily) the rCBF is
unaffected, but it is increased significantly if higher doses (greater than
120 mg/daily) are used. In all six patients who served as their own
control, as they had basic rCBF measurements before or during low-dose
propranolol, the rCBF on high-dose propranolol became significantly
increased. The possible mechanisms which may cause the increased rCBF on
high-dose propranolol are discussed.
ARTICLES
The effect of chronic propranolol therapy on regional cerebral blood flow in hypertensive patients
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