Stroke, Vol 14, 977-982, Copyright © 1983 by American Heart Association
M Yamamoto, T Shima, T Uozumi, T Sogabe, K Yamada and T Kawasaki
Incomplete global cerebral ischemia was induced by clamping the bilateral
common carotid arteries of spontaneously hypertensive rats (SHR) and blood
reperfusion was allowed by declamping the arteries after indicated times.
To investigate the possible role of lipid peroxidation which causes
irreversible ischemic cell injury during ischemia and subsequent
reperfusion, cerebral energy metabolism, brain edema, neurological signs
and cerebral and serum lipid peroxides were examined. The effect of
alpha-tocopherol administration on these parameters was also studied from
the standpoint of its action as a free radical scavenger. During ischemia
up to 5 hours, cerebral ATP decreased and lactate increased rapidly, and
concomitantly neurological signs, such as eye closure and jumping seizures,
and slowly progressing brain edema were observed. The level of lipid
peroxides in the brain and serum remained practically unchanged during
ischemia, although an increasing tendency was noted. When blood reperfusion
was allowed 3 hours after ischemia, tissue ATP level was restored only
partially (67.4% of normal), but lactate returned to the normal level. The
reperfusion resulted in a rapid rise in the lipid peroxide level both in
cerebral tissue and serum and also caused a more severe expression of
neurological signs. Intravenous injection of alpha-tocopherol (20 mg/kg
body weight) 30 minutes prior to ligation of the carotid arteries
significantly suppressed the rise in lipid peroxides both in the brain and
serum, improved the severely expressed neurological signs, and promoted
resynthesis of ATP. These improvements in the parameters were observed only
after the reperfusion was made following ischemia for 3 hours.(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of alpha-tocopherol administration
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