This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sage, J. I. Articles by Duffy, T. E. Search for Related Content PubMed PubMed Citation Articles by Sage, J. I. Articles by Duffy, T. E.

Stroke, Vol 15, 46-50, Copyright © 1984 by American Heart Association

ARTICLES

Early changes in blood brain barrier permeability to small molecules after transient cerebral ischemia

JI Sage, RL Van Uitert and TE Duffy

Brain unidirectional extraction and flux of leucine were measured simultaneously with cerebral blood flow (CBF) at various times after transient global cerebral ischemia in the rat. The results permit an evaluation of blood-brain barrier permeability in the postischemic period independent of alterations in CBF at the time of measurement. Leucine extraction was higher (p less than 0.001) than that of CBF- matched controls at 15 min and 6 hr after 30 min of global cerebral ischemia, but was not different from control at 30 min and 1 h after ischemia. Leucine flux into brain was increased only at 15 min after reperfusion of the brain. Cerebral edema occurs 15-30 min after reperfusion in this ischemia model, but the permeability of the blood- brain barrier to large molecules is unaltered during this period (Petito et al: J Neuropath Exp Neurol 41:423-436, 1982). Increased barrier permeability to small molecules such as leucine may contribute to the production of this early postischemic edema.

This article has been cited by other articles:

				B. Chen, B. Friedman, Q. Cheng, P. Tsai, E. Schim, D. Kleinfeld, and P. D. Lyden Severe Blood-Brain Barrier Disruption and Surrounding Tissue Injury Stroke, December 1, 2009; 40(12): e666 - e674. [Abstract] [Full Text] [PDF]

				G. Giannakoulas, A. Hatzitolios, H. Karvounis, G. Koliakos, A. Charitandi, T. Dimitroulas, C. Savopoulos, E. Tsirogianni, and G. Louridas N-Terminal Pro-Brain Natriuretic Peptide Levels Are Elevated in Patients with Acute Ischemic Stroke Angiology, November 1, 2005; 56(6): 723 - 730. [Abstract] [PDF]

				T. J. Abbruscato and T. P. Davis Combination of Hypoxia/Aglycemia Compromises In Vitro Blood-Brain Barrier Integrity J. Pharmacol. Exp. Ther., May 1, 1999; 289(2): 668 - 675. [Abstract] [Full Text]

				R. Veltkamp, F. Domoki, F. Bari, D. W. Busija, and W. G. Mayhan Potassium Channel Activators Protect the N-Methyl-D-Aspartate–Induced Cerebral Vascular Dilation After Combined Hypoxia and Ischemia in Piglets • Editorial Comment Stroke, April 1, 1998; 29(4): 837 - 843. [Abstract] [Full Text] [PDF]

				A. Jacobs Amino Acid Uptake in Ischemically Compromised Brain Tissue Stroke, October 1, 1995; 26(10): 1859 - 1866. [Abstract] [Full Text]

				A. Wallin and K. Blennow Heterogeneity of Vascular Dementia: Mechanisms and Subgroups J Geriatr Psychiatry Neurol, July 1, 1993; 6(3): 177 - 188. [Abstract] [PDF]

				S. Endo, P. J. Branson, and J. F. Alksne Angiographic Investigation of the Development of Collateral Circulation in the Rabbit Vascular and Endovascular Surgery, May 1, 1989; 23(3): 201 - 207. [Abstract] [PDF]