This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Volpe, B. T. Articles by Davis, H. P. Search for Related Content PubMed PubMed Citation Articles by Volpe, B. T. Articles by Davis, H. P.

Stroke, Vol 15, 558-562, Copyright © 1984 by American Heart Association

ARTICLES

Behavioral performance of rats following transient forebrain ischemia

BT Volpe, WA Pulsinelli, J Tribuna and HP Davis

Rats subjected to transient forebrain ischemic injury by the method of four vessel occlusion (4-VO) develop irreversible injury to select populations of vulnerable neurons which include pyramidal cells in the CA-1 region of the hippocampus. This brain area is thought to be crucial for learning and memory. Rats subjected to 30 minutes of 4-VO, and then cerebral reperfusion were tested on a radial 8-arm maze task after they had recovered. The data shows that both 4-VO and control animals improve their performance over trials, but that 4-VO rats are impaired on "working" and "reference" tasks. The data suggest that 4-VO rats' impaired "working" performance is permanent, compared to their transient "reference" impairment. Alterations in sensorimotor activity could not account for these performance deficits since control and 4-VO rats demonstrated equivalent choice time per maze arm. Performance deficits in rats following forebrain ischemic injury may be similar to some of the cognitive deficits found in humans survivors of cerebral hypoxia-ischemia.

This article has been cited by other articles:

				J. Epsztein, Y. Ben-Ari, A. Represa, and V. Crepel Late-Onset Epileptogenesis and Seizure Genesis: Lessons From Models of Cerebral Ischemia Neuroscientist, February 1, 2008; 14(1): 78 - 90. [Abstract] [PDF]

				G. S. Mitchell and S. M. Johnson Plasticity in Respiratory Motor Control: Invited Review: Neuroplasticity in respiratory motor control J Appl Physiol, January 1, 2003; 94(1): 358 - 374. [Abstract] [Full Text] [PDF]

				M. E. Martone, Y. Z. Jones, S. J. Young, M. H. Ellisman, J. A. Zivin, and B.-R. Hu Modification of Postsynaptic Densities after Transient Cerebral Ischemia: A Quantitative and Three-Dimensional Ultrastructural Study J. Neurosci., March 15, 1999; 19(6): 1988 - 1997. [Abstract] [Full Text] [PDF]

				R. P. Wiard, M. C. Dickerson, O. Beek, R. Norton, and B. R. Cooper Neuroprotective Properties of the Novel Antiepileptic Lamotrigine in a Gerbil Model of Global Cerebral Ischemia Stroke, March 1, 1995; 26(3): 466 - 472. [Abstract] [Full Text]

				L. Squire and S Zola-Morgan The medial temporal lobe memory system Science, September 20, 1991; 253(5026): 1380 - 1386. [Abstract] [PDF]

				L. Squire Mechanisms of memory Science, June 27, 1986; 232(4758): 1612 - 1619. [Abstract] [PDF]