Stroke, Vol 15, 950-955, Copyright © 1984 by American Heart Association
T Brott and K Thalinger
All carotid endarterectomies performed in the greater Cincinnati
metropolitan area during 1980 were reviewed. For the 431 procedures
performed in 16 hospitals, the operative stroke rate was 8.6% (37 of 431),
and the operative mortality rate was 2.8% (12 of 431). The combined
morbidity and mortality was 9.5% (41 of 431). Fifty percent of the
procedures were done for asymptomatic carotid disease (216 of 431) and 50%
were done for symptomatic carotid disease (215 of 431). The stroke rate was
5.6% for the asymptomatic patients and 11.6% for the symptomatic patients
(difference significant, p less than 0.05). Neurosurgeons and vascular
surgeons had similar surgical morbidity. All of the operative strokes
involved the hemisphere ipsilateral to the endarterectomy. Fifty-seven
percent of the operative strokes (21 of 37) occurred after a neurologically
intact interval lasting hours to days. Four occurred following combined
endarterectomy-coronary bypass surgery, and one was an intracerebral
hemorrhage. The other late strokes (17) occurred without evidence for
cardiac embolus or hemorrhage, consistent with a thrombogenic-embologenic
operative site, and raising the question of need for adjunctive
perioperative medical therapy.
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The practice of carotid endarterectomy in a large metropolitan area
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