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Stroke, Vol 16, 406-415, Copyright © 1985 by American Heart Association
The Persantine Aspirin Trial focused on the question of whether the
administration of the combination of aspirin and dipyridamole (Persantine)
would result in a lower incidence of cerebral or retinal infarction or
death than the administration of aspirin alone for persons with a history
of recent carotid territory transient ischemic attacks (TIAs). Fifteen
centers in the United States and Canada participated and 890 individuals
were admitted and randomly allocated to either aspirin (325 mg) plus
placebo or aspirin (325 mg) plus Persantine (75 mg) four times daily.
Ninety eight percent of the subjects were followed for at least one year;
many were followed for four to five years. The results of life table
analysis indicate that the overall endpoint rates for the "aspirin only"
and "aspirin plus Persantine" groups are identical. Thus, for TIA patients
taking aspirin, the addition of Persantine contributes nothing. There was a
clustering of stroke endpoints during the first month after randomization.
Deaths from all causes were essentially equally divided between the two
treatment groups.
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Persantine Aspirin Trial in cerebral ischemia. Part II: Endpoint results. The American-Canadian Co-Operative Study group
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