This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lundy, E. F. Articles by D'Alecy, L. G. Search for Related Content PubMed PubMed Citation Articles by Lundy, E. F. Articles by D'Alecy, L. G.

Stroke, Vol 16, 855-860, Copyright © 1985 by American Heart Association

ARTICLES

Reduction of neurologic deficit by 1,3-butanediol induced ketosis in levine rats

EF Lundy, J Dykstra, B Luyckx, GB Zelenock and LG D'Alecy

The objective of this study was to determine if 1,3-butanediol would reduce a neurologic deficit in rats exposed to ischemic-hypoxia (Levine rats). Age and weight matched male Sprague-Dawley rats were anesthetized with 2% halothane. The right common carotid and external jugular vein were ligated and cannulated and EEG screws were implanted followed by a 2 hour recovery period. Thirty minutes prior to exposure the rats received either 1,3-butanediol (47 mmole/kg i.v.; n = 11) or an equal volume of saline (n = 10). The rats were then exposed to 4.5% O2 until mean arterial blood pressure fell to 70 mm Hg. The oxygen level was then increased to 8% for 30 minutes, after which the rats were returned to room air. Posture, hemiparesis, circling, shuffling, activity, and ability to hang on to a vertical screen were scored 1 (normal) to 5 (severe deficit) at 2 and 20 hours after insult. The time to 70 mm Hg was extended from 7.9 +/- 0.9 min for saline treated rats to 19.0 +/- 2.3 min for the 1,3-butanediol treated rats (p less than 0.001). All eleven 1,3-butanediol treated rats survived the hypoxic insult; 90% (9/10) saline treated rats died. In an attempt to reduce the insult, six additional saline treated rats were switched to 8% O2 at 75 mm Hg and still 4/6 died. The mean score at 20 hours for three surviving saline treated rats was 3.4. A significantly better (p less than 0.002) mean 20 hour score for the surviving 8/11 1,3-butanediol treated rats was 1.2. 1,3-butanediol increases survival and decreases the neurologic deficits associated with this ischemic-hypoxic insult.

This article has been cited by other articles:

				D. Long and J. Young Dexamphetamine treatment in stroke QJM, September 1, 2003; 96(9): 673 - 685. [Abstract] [Full Text] [PDF]

				L. Martinsson and N. G. Wahlgren Safety of Dexamphetamine in Acute Ischemic Stroke: A Randomized, Double-Blind, Controlled Dose-Escalation Trial Stroke, February 1, 2003; 34(2): 475 - 481. [Abstract] [Full Text] [PDF]