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Stroke, Vol 16, 871-874, Copyright © 1985 by American Heart Association

ARTICLES

Measurement of cerebral blood flow during xenon inhalation as measured by the microspheres method

D Gur, H Yonas, DL Jackson, SK Wolfson Jr, H Rockette, WF Good, GS Maitz, EE Cook and VC Arena

Measurements of cerebral blood flow (CBF) were performed using the microsphere technique in non-human primates (baboons) to assess the effect of non-radioactive xenon gas inhalation on CBF. Blood flows in small tissue volumes (approximately 1 cm3) were directly measured before and during the inhalation of xenon/oxygen gas mixtures. The results of these studies demonstrated that when inhaled in relatively high concentrations, xenon gas does increase CBF, but the changes are more global than tissue-specific. The problems and limitations of such evaluations are discussed.

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