Stroke, Vol 17, 185-192, Copyright © 1986 by American Heart Association
D Inzitari, F Bianchi, G Pracucci, V Albanese, C Argentino, G Bono, GL Brambilla, L Candelise, L De Zanche and F Mariani
Utilizing the initial BP assessment in the 462 patients who entered the
Italian Multicenter Study of reversible cerebral ischemia, an analysis of
the effect of each BP component in respect of presence, extent and severity
of atherosclerotic lesions, as displayed by angiography, was carried out
separately for lesions located at either intra- or extracranial level. In a
multivariate statistical model, among the following variables: sex, age,
systolic BP, diastolic BP, cholesterol and smoking, systolic BP was found
the best predictor of extent and severity of atherosclerotic lesions at
extracranial level. None of the same variables was predictive of the
severity of intracranial atherosclerosis. The results of this clinical
study may confirm the indication, coming from physiopathologic
observations, of a predominant role of systolic hypertension in the process
of maintenance and acceleration of atherosclerosis in the large
pre-cerebral arteries.
ARTICLES
The Italian Multicenter Study of reversible cerebral ischemic attacks: IV--Blood pressure components and atherosclerotic lesions
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