Stroke, Vol 17, 246-253, Copyright © 1986 by American Heart Association
JM Hallenbeck, AJ Dutka, T Tanishima, PM Kochanek, KK Kumaroo, CB Thompson, TP Obrenovitch and TJ Contreras
In an anesthetized canine model in which ischemia was induced by
incremental air embolism, 16 animals were exposed to 1 hr of ischemia and
monitored for 10 min (n = 4), 60 min (n = 6), or 240 min (n = 6). Fourteen
animals were observed for corresponding periods without being subjected to
ischemia 70 min (n = 4), 120 min (n = 4), or 300 min (n = 6). Autologous
granulocytes were labeled with 111In and reinfused just before ischemia. At
the conclusion of each experiment, a 14C- iodoantipyrine autoradiographic
blood flow study was performed. Granulocyte accumulation measured by gamma
scintigraphy (cpm/gm) occurred in the injured hemisphere of ischemic
animals at 60 min in anterior brain segments and at 240 min in anterior,
middle, and posterior segments. By means of a double-label autoradiography
technique, clustering of punctate granulocyte images was detected in
regions of low flow or heterogeneous flow in half of the animals at both 60
min and 240 min postischemia. Granulocyte clustering did not occur in the
autoradiograms of nonischemic animals. The results implicate granulocyte
participation in the acute phase of ischemic brain injury and signal a
convergence of hemostatic and inflammatory processes during the immediate
postischemic period.
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Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period
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