Donate Help Contact The AHA Sign In Home
American Heart Association
Stroke
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Stroke. 1986;17:692-698

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Herold, S.
Right arrow Articles by Jones, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Herold, S.
Right arrow Articles by Jones, T.

Stroke, Vol 17, 692-698, Copyright © 1986 by American Heart Association

ARTICLES

Measurement of regional cerebral blood flow, blood volume and oxygen metabolism in patients with sickle cell disease using positron emission tomography

S Herold, M Brozovic, J Gibbs, AA Lammertsma, KL Leenders, D Carr, JS Fleming and T Jones

Regional cerebral blood flow, blood volume, fractional oxygen extraction and oxygen consumption were measured by positron emission tomography in six patients with sickle cell disease to see how oxygen delivery to the brain is maintained in the presence of both anemia and a low oxygen affinity hemoglobin. Both regional cerebral blood flow and blood volume were found to be markedly increased compared to values obtained from 14 normal subjects in the same age range. The mean fractional oxygen extraction was not significantly different in the two groups. Mean oxygen consumption in the two groups was also not significantly different but low values in individual patients with sickle cell disease and the presence of atrophy on the CT-scans of three of them were suggestive of some neuronal loss in patients without any history of nervous system involvement. In view of the known high values of cerebral blood flow and metabolism in childhood, it is suggested that when compounded by anemia and abnormal red cells, a hypercirculatory state may make patients in this age-group particularly prone to ischemic infarction.


This article has been cited by other articles:


Home page
 RadiologyHome page
K. K. Oguz, X. Golay, F. B. Pizzini, C. A. Freer, N. Winrow, R. Ichord, J. F. Casella, P. C. M. van Zijl, and E. R. Melhem
Sickle Cell Disease: Continuous Arterial Spin-labeling Perfusion MR Imaging in Children
Radiology, May 1, 2003; 227(2): 567 - 574.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
R. J. Adams, K. Ohene-Frempong, and W. Wang
Sickle Cell and the Brain
Hematology, January 1, 2001; 2001(1): 31 - 46.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. R. Powars, P. S. Conti, W.-Y. Wong, P. Groncy, C. Hyman, E. Smith, N. Ewing, R. N. Keenan, C.-S. Zee, Y. Harold, et al.
Cerebral Vasculopathy in Sickle Cell Anemia: Diagnostic Contribution of Positron Emission Tomography
Blood, January 1, 1999; 93(1): 71 - 79.
[Abstract] [Full Text] [PDF]

Home page
 J Learn DisabilHome page
R. T. Brown, F. D. Armstrong, and J. R. Eckman
Neurocognitive Aspects of Pediatric Sickle Cell Disease
J Learn Disabil, January 1, 1993; 26(1): 33 - 45.
[Abstract] [PDF]


Stroke Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1986 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.