This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fujisawa, A. Articles by Kamada, T. Search for Related Content PubMed PubMed Citation Articles by Fujisawa, A. Articles by Kamada, T.

Stroke, Vol 17, 748-752, Copyright © 1986 by American Heart Association

ARTICLES

The effect of the calcium antagonist nimodipine on the gerbil model of experimental cerebral ischemia

A Fujisawa, M Matsumoto, T Matsuyama, H Ueda, A Wanaka, S Yoneda, K Kimura and T Kamada

The gerbil model was used to assess the therapeutic effects of the calcium antagonist nimodipine on cerebral ischemia. Transient cerebral ischemia was produced in each gerbil by bilateral common carotid occlusion of 10-, 15- or 20-min duration. Nimodipine (0.01 or 0.1 mg/kg) was administered intraperitoneally just before the carotid occlusion or 10-30 min after the removal of the arterial clips. Morbidity of each animal was evaluated using the stroke index, and the sum of stroke indices was calculated for evaluating the overall morbidity during a particular period of reperfusion. Mortality was observed for 24 hours after clip removal. Although, depending on the timing of the drug administration, the low-dose (0.01 mg/kg) nimodipine worsened the morbidity in the gerbils with 10-min ischemia, the high- dose (0.1 mg/kg) of the drug had a clear beneficial effect on the mortality associated with cerebral ischemia. These results are considered worthwhile for further trials to assess the usefulness of nimodipine as a therapeutic agent in the management of the acute ischemic stroke.

This article has been cited by other articles:

				L. B. Goldstein Pharmacologic Modulation of Recovery After Stroke: Clinical Data Neurorehabil Neural Repair, January 1, 1991; 5(1-2): 129 - 140. [PDF]