Stroke, Vol 17, 831-835, Copyright © 1986 by American Heart Association
R Bonita
A case-control analysis is used to examine the relation of cigarette
smoking, hypertension and the risk of subarachnoid hemorrhage in men and
women aged 35-64 years. 45 men and 70 women with subarachnoid hemorrhage
were identified as part of a large community based study of stroke, and the
controls, 1017 men and 569 women, came from a survey of cardiovascular risk
factors conducted in the same community. Cigarette smokers, after adjusting
for age, had a significantly increased risk of subarachnoid hemorrhage
compared with nonsmokers with relative risks of 3.0 for men and 4.7 for
women. The strength of the risk increased with the amount smoked. The
association remained significant for each sex after adjusting for
hypertension. Those who both smoked and had a history of hypertension had
an increased risk of subarachnoid hemorrhage of almost 15 fold compared to
those who neither smoked nor had been treated for hypertension. The
estimated population attributable risk of subarachnoid hemorrhage
associated with cigarette smoking (43%) was greater than that of
hypertension (28%) in this population.
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Cigarette smoking, hypertension and the risk of subarachnoid hemorrhage: a population-based case-control study
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