Stroke, Vol 17, 835-841, Copyright © 1986 by American Heart Association
M Kojima, H Handa, N Hashimoto, C Kim and F Hazama
To obtain information about the early changes of experimentally induced
cerebral aneurysms in rats, the luminal surface of branching areas of their
cerebral arteries was examined with a scanning electron microscope. At the
branching sites of major cerebral arteries in the control animals, the
intima just distal to the apex markedly protruded into the lumen forming a
linear bank-like intimal pad. Along and distal to this pad, there was a
shallow long groove (juxta-apical groove). Such grooves were much deeper
and wider in experimental animals than those in the control rats. By
studying various stages of early aneurysmal changes, cerebral aneurysms
were proven to develop from such grooves. In deep juxta-apical grooves and
small aneurysms, round regenerated endothelial cells with a large number of
microvilli were diffusely present. Degenerated cells with balloons and
craters were observed intermingled with such regenerated cells.
Interendothelial gaps were also seen. The present study showed the complex
structure of the apex of arterial bifurcation in rats, including bank-like
intimal pads. Such complex structures of the branching sites were
considered to be responsible for the initiation of cerebral aneurysms due
to endothelial injury possibly caused by turbulent flow there.
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Early changes of experimentally induced cerebral aneurysms in rats: scanning electron microscopic study
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