Stroke, Vol 17, 942-945, Copyright © 1986 by American Heart Association
G Zenker, P Koltringer, G Bone, K Niederkorn, K Pfeiffer and G Jurgens
To evaluate the role of lipoprotein(a) (Lp(a] in patients with
cerebrovascular disease (CVD), lipid parameters were compared with a
control group (CO). Additionally, the Lp(a) serum levels were investigated
in a coronary artery disease (CAD) group. The CO was made up of 37 healthy
persons (age: 54.5 +/- 7.7, 26 males and 11 females), the CVD group
included 46 patients with sustained transient ischemic attack (TIA)
prolonged reversible ischemic neurologic deficits (PRIND) and cerebral
infarction (CI) (age: 53.6 +/- 9.7, 32 males and 14 females), and the CAD
group was made up of 28 survivors of myocardial infarctions (age: 52.5 +/-
8.1, 18 males and 10 females). The median values of Lp(a) in CVD were
significantly higher than in the CO (p less than 0.01) and did not differ
significantly from the CAD. Total TC, HDL- C, TG, LDL-C and the ratio of
LDL-C/HDL-C did not show any significant difference between the control and
cerebrovascular disease group. For quantification of the vascular lesions
of the carotid system, a Duplex Doppler score system was used. The score
correlated with Lp(a) in patients between 40 to 65 years of age (r = 0.34,
p less than 0.01). Thus, we conclude that Lp(a) is not only a risk factor
for CAD but also for CVD.
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Lipoprotein(a) as a strong indicator for cerebrovascular disease
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