This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fujishima, M. Articles by Sadoshima, S. Search for Related Content PubMed PubMed Citation Articles by Fujishima, M. Articles by Sadoshima, S.

Stroke, Vol 17, 985-988, Copyright © 1986 by American Heart Association

ARTICLES

Effects of long-term antihypertensive treatment on cerebral, thalamic and cerebellar blood flow in spontaneously hypertensive rats (SHR)

M Fujishima, S Ibayashi, K Fujii, H Yao and S Sadoshima

Cerebral blood flows (CBF) were measured in the parietal cortex, the thalamus and the cerebellum by the hydrogen clearance technique in anesthetized spontaneously hypertensive rats, of which hypertension was treated for 16 weeks (long-term) or 8 weeks (short-term) with antihypertensive agents of hydralazine and guanethidine. As compared to non-treated control animals, CBF in the three regions were significantly increased while the calculated cerebrovascular resistances (CVR) were decreased in hypertension-treated animals. Such CBF and CVR changes were greater in SHR with long-term than short-term therapy. Both an increase in CBF and a decrease in CVR were closely related to a fall in the blood pressure. From the present results, it was concluded that earlier and longer treatment of hypertension could lessen or even prevent the increased CVR due to the hypertensive vascular changes, and increase CBF as a result.

This article has been cited by other articles:

				H. Nakane, S. Ibayashi, K. Fujii, K. Irie, S. Sadoshima, and M. Fujishima Cerebral Blood Flow and Metabolism in Hypertensive Patients with Cerebral Infarction Angiology, September 1, 1995; 46(9): 801 - 810. [Abstract] [PDF]