This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yamaguchi, T. Articles by Suzuki, K. Search for Related Content PubMed PubMed Citation Articles by Yamaguchi, T. Articles by Suzuki, K.

Stroke, Vol 17, 1220-1228, Copyright © 1986 by American Heart Association

ARTICLES

Reduction in regional cerebral metabolic rate of oxygen during human aging

T Yamaguchi, I Kanno, K Uemura, F Shishido, A Inugami, T Ogawa, M Murakami and K Suzuki

To investigate changes in cerebral circulation and oxygen metabolism during aging, regional cerebral blood flow (rCBF), regional oxygen extraction fraction (rOEF), regional cerebral metabolic rate of oxygen (rCMRO2) and regional cerebral blood volume (rCBV) were measured using the 15O labelled gas inhalation technique and a multi-slice positron emission tomograph (PET) in 22 healthy volunteers, aged from 26 to 64 years old. The measurements were performed with subjects at rest, without sensory deprivation. The values of rCBF, rOEF, rCMRO2 and rCBV in more than 40 anatomical structures of the brain were evaluated by studying a large series of scans in each region of interest after the functional PET image had been anatomically identified using x-ray computed tomographic images corresponding to the PET. In mean gray values, only CMRO2 showed significant reduction with age. rCMRO2 significantly decreased with age only in the supratentrium, and much more in the left hemisphere. Especially remarkable was rCMRO2 reduction in the left caudate region. Both CBF and OEF were variable and less age- dependent. It was concluded that CMRO2 could be reflecting healthy brain aging most properly.

This article has been cited by other articles:

				H. Kimura, H. Takeuchi, Y. Koshimoto, H. Arishima, H. Uematsu, Y. Kawamura, T. Kubota, and H. Itoh Perfusion Imaging of Meningioma by Using Continuous Arterial Spin-Labeling: Comparison with Dynamic Susceptibility-Weighted Contrast-Enhanced MR Images and Histopathologic Features AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 85 - 93. [Abstract] [Full Text] [PDF]

				O. O. Aalami, T. D. Fang, H. M. Song, and R. P. Nacamuli Physiological Features of Aging Persons Arch Surg, October 1, 2003; 138(10): 1068 - 1076. [Full Text] [PDF]

				S. Arakawa, K. Minematsu, T. Hirano, Y. Tanaka, Y. Hasegawa, K. Hayashida, and T. Yamaguchi Topographic Distribution of Misery Perfusion in Relation to Internal and Superficial Borderzones AJNR Am. J. Neuroradiol., March 1, 2003; 24(3): 427 - 435. [Abstract] [Full Text] [PDF]

				K. Yamada, R. G. Gonzalez, L. Ostergaard, S. Komili, R. M. Weisskoff, B. R. Rosen, W. J. Koroshetz, T. Nishimura, and A. G. Sorensen Iron-Induced Susceptibility Effect at the Globus Pallidus Causes Underestimation of Flow and Volume on Dynamic Susceptibility Contrast-Enhanced MR Perfusion Images AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1022 - 1029. [Abstract] [Full Text] [PDF]

				H. Kado, H. Kimura, T. Tsuchida, Y. Yonekura, T. Tokime, Y. Tokuriki, and H. Itoh Abnormal Magnetization Transfer Ratios in Normal-appearing White Matter on Conventional MR Images of Patients with Occlusive Cerebrovascular Disease AJNR Am. J. Neuroradiol., May 1, 2001; 22(5): 922 - 927. [Abstract] [Full Text]

				K. Kikuchi, K. Murase, H. Miki, T. Kikuchi, Y. Sugawara, T. Mochizuki, J. Ikezoe, and S. Ohue Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide 133Xe-SPECT in Occlusive Carotid Disease AJNR Am. J. Neuroradiol., February 1, 2001; 22(2): 248 - 254. [Abstract] [Full Text] [PDF]

				C. Cidis Meltzer, M. N. Cantwell, P. J. Greer, D. Ben-Eliezer, G. Smith, G. Frank, W. H. Kaye, P. R. Houck, and J. C. Price Does Cerebral Blood Flow Decline in Healthy Aging? A PET Study with Partial-Volume Correction J. Nucl. Med., November 1, 2000; 41(11): 1842 - 1848. [Abstract] [Full Text] [PDF]

				Takahashi, Shirane, Sato, and Yoshimoto Developmental Changes of Cerebral Blood Flow and Oxygen Metabolism in AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 917 - 922. [Abstract] [Full Text]

				M. Ernst, A. J. Zametkin, R. L. Phillips, and R. M. Cohen Age-Related Changes in Brain Glucose Metabolism in Adults With Attention-Deficit/Hyperactivity Disorder and Control Subjects J Neuropsychiatry Clin Neurosci, May 1, 1998; 10(2): 168 - 177. [Abstract] [Full Text]

				W. E. Rinn Mental Decline in Normal Aging: A Review J Geriatr Psychiatry Neurol, July 1, 1988; 1(3): 144 - 158. [Abstract] [PDF]