This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Laycock, J. R. Articles by Walters, F. J. Search for Related Content PubMed PubMed Citation Articles by Laycock, J. R. Articles by Walters, F. J.

Stroke, Vol 17, 1242-1246, Copyright © 1986 by American Heart Association

ARTICLES

Effect of carotid artery ligation and infusion of fluosol FC-43 emulsion on brain surface oxygen tensions

JR Laycock, HB Coakham, IA Silver and FJ Walters

In eight rabbits, the common carotid artery was ligated and multiple estimations of brain surface oxygen tension performed using a seven barrelled mini-electrode. In five rabbits ligation of the carotid artery resulted in impairment of cortical oxygenation. The remaining three rabbits showed no impairment in the supply of oxygen to the cerebral cortex after carotid occlusion. In the five rabbits who displayed a reduction in oxygen supply after carotid ligation, ventilation with 33% oxygen after the infusion of 15 ml/kg of Fluosol FC-43 produced an improvement in cortical oxygenation in only three of the five rabbits. When these animals were ventilated with 100% oxygen after carotid ligation and Fluosol infusion, oxygen supply in all five was commensurate with or greater than that during control conditions.