This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vibulsresth, S. Articles by Ginsberg, M. D. Search for Related Content PubMed PubMed Citation Articles by Vibulsresth, S. Articles by Ginsberg, M. D.

Stroke, Vol 18, 210-216, Copyright © 1987 by American Heart Association

ARTICLES

Failure of nimodipine to prevent ischemic neuronal damage in rats

S Vibulsresth, WD Dietrich, R Busto and MD Ginsberg

The efficacy of nimodipine in preventing ischemic brain injury was tested in rats subjected to a 20-minute period of high-grade forebrain ischemia by 4-vessel occlusion. Three minutes after restoration of circulation to the brain, an intravenous bolus of 5 micrograms/kg nimodipine or an equivalent amount of vehicle or saline was given, followed by continuous intravenous infusion of the respective solution at 1 microgram/kg/min for 2 hours. In a second series, a larger bolus (20 micrograms/kg of nimodipine) and longer infusion period (6 hours) were employed. Histopathology of the brain was evaluated blindly 72 hours later and graded on a conventional 3-point scale. There was no significant effect of treatment in either series. In the 6-hour series, the percent of cerebral hemispheres showing damage of Grades 2 or 3 in zone CA1 of the hippocampus and in the striatum, respectively, was 100 and 40% for the nimodipine-treated rats, 100 and 42% for rats receiving vehicle, and 75 and 25% for animals receiving saline. Thus, this study revealed no beneficial effect of nimodipine when given following a 20- minute period of severe forebrain ischemia.

This article has been cited by other articles:

				G. H. Danton and W. D. Dietrich The Search for Neuroprotective Strategies in Stroke AJNR Am. J. Neuroradiol., February 1, 2004; 25(2): 181 - 194. [Full Text] [PDF]

				T. Tatlisumak, K. Takano, R. A. D. Carano, L. P. Miller, A. C. Foster, M. Fisher, C. Y. Hsu, and W. Lin Delayed Treatment With an Adenosine Kinase Inhibitor, GP683, Attenuates Infarct Size in Rats With Temporary Middle Cerebral Artery Occlusion • Editorial Comment Stroke, September 1, 1998; 29(9): 1952 - 1958. [Abstract] [Full Text] [PDF]

				J. M. Roda, F. Carceller, E. Diez-Tejedor, and C. Avendano Reduction of Infarct Size by Intra-Arterial Nimodipine Administered at Reperfusion in a Rat Model of Partially Reversible Brain Focal Ischemia Stroke, October 1, 1995; 26(10): 1888 - 1892. [Abstract] [Full Text]

				V. S. Miller Topical Review Article: Pharmacologic Management of Neonatal Cerebral Ischemia and Hemorrhage: Old and New Directions J Child Neurol, January 1, 1993; 8(1): 7 - 18. [Abstract] [PDF]

				L. B. Goldstein Pharmacologic Modulation of Recovery After Stroke: Clinical Data Neurorehabil Neural Repair, January 1, 1991; 5(1-2): 129 - 140. [PDF]

				K. Maiese and J. J. Caronna Coma Following Cardiac Arrest: A Review of the Clinical Features, Management, and Prognosis J Intensive Care Med, May 1, 1988; 3(3): 153 - 163. [Abstract] [PDF]