Stroke, Vol 18, 335-341, Copyright © 1987 by American Heart Association
RL Rogers, JS Meyer and KF Mortel
A 7-year prospective study of a cohort of 107 neurologically normal elderly
hypertensive volunteers (mean age, 65.8 +/- 8.3 years) was undertaken to
investigate the predictive validities of additional risk factors for
atherothrombotic cerebrovascular disease including stroke, transient
ischemic attacks, reversible ischemic neurological deficits, and
multi-infarct dementia. This longitudinal study has been in progress now
for 7 years with a mean follow-up interval of 50.12 +/- 5.76 months. Among
107 formerly symptom-free, normal hypertensive volunteers, 25 (23%) have
developed cerebrovascular disease, 7 (6.5%) sustained a stroke, 10 (9.3%)
developed multi-infarct dementia, and 18 (16.8%) have transient ischemic
attacks. None have suffered intracranial hemorrhage. Mean gray matter
cerebral blood flow (CBF) values measured at the initial visit were
sensitive predictors of cerebrovascular disease. Eight of 16 hypertensives
(50%) with initial CBF values below 60.0 ml/100 g/min now exhibit signs and
symptoms of cerebrovascular disease, while 11 of 43 hypertensives (25.6%)
with initial CBF values between 60.1 and 69.9 ml/100 g/min and only 6 of 48
(12.5%) with initial CBF levels above 70.0 developed cerebrovascular
disease. Incidence of cerebrovascular disease among cigarette smoking
hypertensive volunteers (32.5%) was significantly greater than among
nonsmokers (17.2%).
ARTICLES
Additional predisposing risk factors for atherothrombotic cerebrovascular disease among treated hypertensive volunteers
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