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Stroke, Vol 18, 373-379, Copyright © 1987 by American Heart Association

ARTICLES

Glycerol and dextran combined in the therapy of acute stroke. A placebo- controlled, double-blind trial with a planned interim analysis

A Frei, C Cottier, P Wunderlich and E Ludin

The results of clinical trials investigating various therapies in acute ischemic stroke have been inconsistent. The effect of glycerol therapy and a combination therapy of glycerol and dextran was evaluated in a double-blind, placebo-controlled study. Repeated neurologic examinations (Day 0, Weeks 1, 6, 12, and 24) according to a modified Mathew score were performed on 62 patients. Statistical analysis showed no superiority of either treatment compared with placebo in acute ischemic stroke. A retrospective estimation of the Type II error of the study yielded approximately p = 0.25. A major side effect was hemolysis in 98% of patients treated with glycerol.

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