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Stroke, Vol 18, 616-622, Copyright © 1987 by American Heart Association

ARTICLES

Comparisons of oxygen metabolism and tissue PO2 in cortex and hippocampus of gerbil brain

PK Nair, DG Buerk and JH Halsey Jr

Recessed oxygen microelectrodes (tip diameter less than 2 microns) were positioned stereotactically into either the cerebral cortex or the hippocampus of sodium pentobarbital anesthetized gerbils (n = 21). The mean tissue PO2 levels (+/- SEM) were not significantly different between cortex (35.4 +/- 1.7 torr) and hippocampus (33.6 +/- 1.4 torr) although differences in the tissue PO2 distributions were seen. The disappearance rate for oxygen (-dPO2/dt) was measured after brief (less than 15 seconds) bilateral carotid artery (total brain blood flow) occlusion. The mean (+/- SEM) disappearance rate was significantly higher (p less than 0.05) in the cortex (23.8 +/- 1.5 torr/sec, 160 locations in 21 gerbils) than in the hippocampus (17.0 +/- 0.7 torr/sec, 119 locations in 16 gerbils). The maximum oxygen consumption rates (VO2max) for Michaelis-Menten kinetics were calculated from the disappearance rates, correcting for gerbil oxyhemoglobin. The mean VO2max was 8.28 +/- 0.51 and 6.13 +/- 0.25 ml O2/100 g/min for the cortex and hippocampus, respectively. The apparent Michaelis-Menten kinetic constants (Km) for the 2 regions were not significantly different (overall mean 3.3 +/- 0.4 torr). Differences in the recovery of tissue PO2 after releasing the occlusion were seen, with more hyperemic responses in the hippocampus.

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