This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kochanek, P. M. Articles by Hallenbeck, J. M. Search for Related Content PubMed PubMed Citation Articles by Kochanek, P. M. Articles by Hallenbeck, J. M.

Stroke, Vol 18, 634-637, Copyright © 1987 by American Heart Association

ARTICLES

Indomethacin, prostacyclin, and heparin improve postischemic cerebral blood flow without affecting early postischemic granulocyte accumulation

PM Kochanek, AJ Dutka and JM Hallenbeck

Six anesthetized dogs treated with indomethacin, prostacyclin (PGI2), and heparin were compared with 7 anesthetized controls (ischemia without treatment) to determine whether cyclooxygenase inhibition would lead to enhanced granulocyte accumulation because of preferential formation of lipoxygenase products. Cortical somatosensory evoked response, [14C]iodoantipyrine autoradiographic blood flow, and 111In- labelled granulocyte accumulation were compared 4 hours after a 60- minute exposure to multifocal brain ischemia. Treatment with indomethacin, PGI2, and heparin eliminated neuron-disabling brain blood flows without altering early postischemic granulocyte accumulation. Granulocyte accumulation after 4 hours of reperfusion was not significantly different in control and treated dogs. The final amplitude of the cortical somatosensory evoked response in the treated group averaged 38.0 +/- 13.6% (mean +/- SEM) of the corresponding baseline value compared with 21.0 +/- 4.6% in the control group, but this difference was not significant.

This article has been cited by other articles:

				K. H. Ryu, B. J. Hindman, D. K. Reasoner, and F. Dexter Heparin Reduces Neurological Impairment After Cerebral Arterial Air Embolism in the Rabbit Stroke, February 1, 1996; 27(2): 303 - 310. [Abstract] [Full Text]