Stroke, Vol 18, 765-770, Copyright © 1987 by American Heart Association
RL Fried and TS Nowak Jr
Peptides derived from each of the 3 endogenous opioid precursors were
measured in gerbil brain regions at various times after transient bilateral
carotid artery occlusion using radioimmunoassays specific for
beta-endorphin-, met-enkephalin-, and dynorphin A-related peptides. Lasting
changes were observed only in the hippocampus. The most striking effect was
on dynorphin A immunoreactivity, which was reduced by 30-40% as early as 1
hour after recirculation and remained at 50% of the control level for at
least 1 week. In some experiments dynorphin levels showed a transient
recovery at 24 hours. These results demonstrate a unique sensitivity of the
dynorphin-containing dentate granule cell-mossy fiber pathway to transient
ischemia. Although these cells remain histologically intact, the decrease
in dynorphin level precedes and continues during the delayed loss of
hippocampal CA1 neurons characteristic of this model and further defines
the selective vulnerability of hippocampal circuitry following ischemia.
These observations clearly identify the hippocampus as a well-defined brain
region in which further studies of the postischemic pathophysiology of
endogenous opioid peptides may provide a rational basis for evaluating the
place of opiate pharmacology in stroke treatment.
ARTICLES
Opioid peptide levels in gerbil brain after transient ischemia: lasting depletion of hippocampal dynorphin
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