Stroke, Vol 18, 771-775, Copyright © 1987 by American Heart Association
R Aaslid
The dynamics of the metabolic mechanism that regulates cerebral blood flow
was studied in 10 normal human subjects using a noninvasive transcranial
ultrasonic Doppler method. Flow volume in the posterior cerebral artery,
supplying the visual cortex, increased 20.2% in response to light
stimulation of the retina, while flow velocity in the same artery increased
16.4%. The regulation of blood flow was very rapid; only 2.3 seconds
elapsed from application of the light stimulus to 50% of full response.
Full regulation (90% of full response) took 4.6 seconds. The blood flow
response adapted slightly after about 10 seconds. Flow velocity in the
middle cerebral artery increased significantly, by 3.3%, while flow in the
superior cerebellar artery showed no significant change in response to this
stimulus. These findings suggest the mechanism of very fast metabolic
regulation of cerebral blood flow in humans.
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Visually evoked dynamic blood flow response of the human cerebral circulation
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