This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lennihan, L. Articles by Quest, D. O. Search for Related Content PubMed PubMed Citation Articles by Lennihan, L. Articles by Quest, D. O.

Stroke, Vol 18, 879-881, Copyright © 1987 by American Heart Association

ARTICLES

Lack of association between carotid plaque hematoma and ischemic cerebral symptoms

L Lennihan, WJ Kupsky, JP Mohr, WA Hauser, JW Correll and DO Quest

To investigate the association between carotid plaque hematoma and symptoms of cerebral ischemia a retrospective review of 200 consecutive carotid endarterectomies at the Neurological Institute of New York was carried out. Data analyzed included cerebral ischemic symptoms, angiographic findings, preoperative use of antithrombotic agents, and microscopic pathology of endarterectomy specimens. No association was found between ischemic symptoms ipsilateral to the endarterectomy and presence, size, or age of plaque hematomas. Plaque hematomas were less common among patients who took antithrombotic agents preoperatively than among those who did not. The presence of plaque hematoma was associated with angiographic carotid cross-sectional area stenosis of greater than 75%. Patients with stenosis of less than 75% were more likely than those with stenosis of greater than 75% to have ischemic symptoms ipsilateral to the endarterectomy, suggesting that criteria for surgical treatment of carotid atherosclerosis differ for those who are symptomatic vs. those who are asymptomatic. These results demonstrate the limitation of using a surgical series to extend causal inferences about the relation between plaque hematoma and cerebral ischemic symptoms to the general population of people with carotid atherosclerosis.

This article has been cited by other articles:

				P. Gao, Z.-q. Chen, Y.-h. Bao, L.-q. Jiao, and F. Ling Correlation Between Carotid Intraplaque Hemorrhage and Clinical Symptoms: Systematic Review of Observational Studies Stroke, August 1, 2007; 38(8): 2382 - 2390. [Abstract] [Full Text] [PDF]

				R. Kern, K. Szabo, M. Hennerici, and S. Meairs Characterization of Carotid Artery Plaques Using Real-time Compound B-mode Ultrasound Stroke, April 1, 2004; 35(4): 870 - 875. [Abstract] [Full Text] [PDF]

				T. J. Tegos, E. Kalodiki, S.-S. Daskalopoulou, and A. N. Nicolaides Stroke: Epidemiology, Clinical Picture, and Risk Factors: Part I of III Angiology, October 1, 2000; 51(10): 793 - 808. [Abstract] [PDF]

				B. Axisa, A. R. Naylor, N. London, P. R. F. Bell, and M. M. Thompson The Influence of Carotid Plaque Morphology on the Development of Cerebral Symptoms Vascular and Endovascular Surgery, July 1, 2000; 34(4): 309 - 318. [Abstract] [PDF]

				J. Golledge, R. M. Greenhalgh, and A. H. Davies The Symptomatic Carotid Plaque Stroke, March 1, 2000; 31(3): 774 - 781. [Abstract] [Full Text] [PDF]

				S. Meairs and M. Hennerici Four-Dimensional Ultrasonographic Characterization of Plaque Surface Motion in Patients With Symptomatic and Asymptomatic Carotid Artery Stenosis Stroke, September 1, 1999; 30(9): 1807 - 1813. [Abstract] [Full Text] [PDF]

				T. A. Manolio, G. L. Burke, D. H. O'Leary, G. Evans, N. Beauchamp, L. Knepper, and B. Ward Relationships of Cerebral MRI Findings to Ultrasonographic Carotid Atherosclerosis in Older Adults : The Cardiovascular Health Study Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 356 - 365. [Abstract] [Full Text] [PDF]

				M.-L. M. Gronholdt Ultrasound and Lipoproteins as Predictors of Lipid-Rich, Rupture-Prone Plaques in the Carotid Artery Arterioscler Thromb Vasc Biol, January 1, 1999; 19(1): 2 - 13. [Abstract] [Full Text] [PDF]

				P.-T. Ko, S.-K. Lin, Y.-J. Chang, S.-J. Ryu, C.-C. Chu, and S.-K. Lin Carotid Floating Plaques Associated with Multiple Cerebral Embolic Strokes: Case Reports Angiology, March 1, 1997; 48(3): 255 - 261. [Abstract] [PDF]

				M. Sitzer, W. Muller, M. Siebler, W. Hort, H.-W. Kniemeyer, L. Jancke, and H. Steinmetz Plaque Ulceration and Lumen Thrombus Are the Main Sources of Cerebral Microemboli in High-grade Internal Carotid Artery Stenosis Stroke, July 1, 1995; 26(7): 1231 - 1233. [Abstract] [Full Text]

				A. Iannuzzi, T. Wilcosky, M. Mercuri, P. Rubba, F. A. Bryan, and M. G. Bond Ultrasonographic Correlates of Carotid Atherosclerosis in Transient Ischemic Attack and Stroke Stroke, April 1, 1995; 26(4): 614 - 619. [Abstract] [Full Text]

				N. M. Bornstein, A. Krajewski, A. J. Lewis, and J. W. Norris Clinical Significance of Carotid Plaque Hemorrhage Arch Neurol, September 1, 1990; 47(9): 958 - 959. [Abstract] [PDF]

				M. Fisher, A. M. Blumenfeld, and T. W. Smith Carotid Plaque Disruption-Reply Arch Neurol, June 1, 1989; 46(6): 605 - 605. [Abstract] [PDF]

				J. R. Feussner and D. B. Matchar When and How to Study the Carotid Arteries Ann Intern Med, November 15, 1988; 109(10): 805 - 818. [Abstract] [PDF]