Stroke, Vol 18, 911-918, Copyright © 1987 by American Heart Association
L Persson, HG Hardemark, J Gustafsson, G Rundstrom, I Mendel-Hartvig, T Esscher and S Pahlman
The development of a radioimmunoassay for S-100 protein is described. This
method was used in combination with a recently developed radioimmunoassay
for neuron-specific enolase in cerebrospinal fluid and serum from 47
patients with cerebral infarction, transient ischemic attack, intracerebral
hemorrhage, subarachnoid hemorrhage, and head injury. In cerebrospinal
fluid, increased concentrations of both S-100 and neuron-specific enolase
were found after large infarcts, whereas after small infarcts and transient
ischemic attacks, only neuron- specific enolase increased. The increased
concentrations of S-100 and/or neuron-specific enolase were noted 18 hours
to 4 days after cerebral infarction and transient ischemic attacks.
Cerebrospinal fluid concentrations of these proteins also reflected the
severity of the disease in patients with intracerebral hematoma,
subarachnoid hemorrhage, or head injury. Temporal changes in serum S-100
and neuron- specific enolase concentrations reflected the clinical course
in 4 patients. In stroke patients, the S-100 and neuron-specific enolase
concentrations may reflect the extent of brain damage and could be useful
in selecting patients with major stroke for more aggressive treatment
during the acute phase.
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S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system
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