Stroke, Vol 18, 1025-1030, Copyright © 1987 by American Heart Association
KF Lindegaard, T Lundar, J Wiberg, D Sjoberg, R Aaslid and H Nornes
Observations on blood velocity in the middle cerebral artery using
transcranial Doppler ultrasound and on the ipsilateral internal carotid
artery flow volume were obtained during periods of transient, rapid blood
flow variations in 7 patients. Five patients were investigated after
carotid endarterectomy. A further 2 patients having staged carotid
endarterectomy and open heart surgery were investigated during nonpulsatile
cardiopulmonary bypass. The patient selection permitted the assumption that
middle cerebral artery flow remained proportional to internal carotid
artery flow. The integrated time-mean values from consecutive 5-second
periods were computed. The arithmetic mean internal carotid artery flow
varied from 167 to 399 ml/min in individual patients, with individual
ranges between +/- 15% and +/- 35% of the mean flow. The mean middle
cerebral artery blood velocity varied from 32 to 78 cm/sec. The relation
between flow volume and blood velocity was nearly linear under these
conditions. Normalization of the data as percent of the individual
arithmetic means permitted a composite analysis of data from all patients.
Linear regression of normalized blood velocity (V') on normalized flow
volume (Q') showed V' = 1.05 Q' - 5.08 (r2 = 0.898).
ARTICLES
Variations in middle cerebral artery blood flow investigated with noninvasive transcranial blood velocity measurements
Department of Neurosurgery, Rikshospitalet, Oslo, Norway.
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