Stroke, Vol 18, 1098-1100, Copyright © 1987 by American Heart Association
P Petersen, EB Madsen, B Brun, F Pedersen, C Gyldensted and G Boysen
Atrial fibrillation (AF) is associated with an increased risk of stroke. In
AF patients with acute stroke, cerebral computed tomography (CT) often
reveals old asymptomatic infarcts. To investigate the frequency of such
lesions, 29 AF patients and 29 controls in sinus rhythm without history of
cerebrovascular disease were CT scanned. Fourteen patients with AF (48%)
had abnormal CT scans with areas of low density with sharp demarcation from
surrounding tissue compared with 8 patients in sinus rhythm (28%) (p
greater than 0.10). However, the number of abnormal areas with apparent
tissue loss was significantly higher in the AF group (39 lesions) compared
with the control group (16 lesions) (p = 0.033). The lesions were mainly
located in the cortex with no significant difference in lesion size between
AF patients and controls. The abnormal areas probably reflected small,
clinically silent infarcts. We conclude that these lesions are present in
AF patients without history of cerebrovascular events and occur more
frequently than in controls without atrial fibrillation.
ARTICLES
Silent cerebral infarction in chronic atrial fibrillation
Department of Neurology, University Hospital, Copenhagen, Denmark.
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