Stroke, Vol 19, 15-18, Copyright © 1988 by American Heart Association
P Petersen and JM Hansen
Chronic atrial fibrillation is associated with an increased risk of stroke.
In elderly patients with thyrotoxicosis, atrial fibrillation is frequently
encountered, and the true risk of cerebrovascular events in these patients
is controversial. We retrospectively studied 610 patients with initially
untreated thyrotoxicosis, 91 (14.9%) of whom had atrial fibrillation, with
the highest frequency in the elderly patients. The risk of cerebrovascular
events, with special attention to the first year after the diagnosis of
thyrotoxicosis, was calculated using logistic regression methods with age,
sex, and atrial fibrillation as independent variables. Only age was an
important risk factor (p less than 0.005), whereas sex and atrial
fibrillation were not significant (p = 0.09 and p = 0.17, respectively) as
independent risk factors. This is contrary to other studies of patients
with thyrotoxic atrial fibrillation, and the need for further clarification
of this issue is clear. From our study the indication for prophylactic
treatment with anticoagulants for prevention of stroke in thyrotoxic atrial
fibrillation seems doubtful, especially as no controlled studies of such
treatment in patients with atrial fibrillation are currently available.
ARTICLES
Stroke in thyrotoxicosis with atrial fibrillation
Department of Internal Medicine and Endocrinology F, Herlev Hospital, Copenhagen, Denmark.
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