Stroke, Vol 19, 1211-1215, Copyright © 1988 by American Heart Association
G Boysen, PS Sorensen, M Juhler, AR Andersen, J Boas, JS Olsen and P Joensen
The effect of very-low-dose aspirin as an antithrombotic agent was
evaluated blindly in 301 patients who had recently undergone carotid
endarterectomy. After randomization, 150 patients received aspirin and 151
received placebo. The two groups were comparable with regard to age, sex,
blood pressure, previous cerebrovascular events, and smoking habits. The
effect of the study medication on platelet aggregation was measured twice
in each patient during the first 2 months and at each follow-up visit; the
dose was individually adjusted. In 76% of the patients receiving aspirin,
50 mg/day gave satisfactory platelet inhibition, 13% needed 60 mg/day, 8%
needed 70 mg/day, and 3% needed 100 mg/day. Platelet aggregation was found
to be inhibited in only 1.2% of the measurements in the patients receiving
placebo. Observation during treatment averaged 21 months; total
intention-to-treat follow-up averaged 25 months. For the combined outcome
events of transient ischemic attack, stroke, acute myocardial infarction,
and vascular death, aspirin reduced risk by 11% (95% confidence limits:
-38% to 48%, p greater than 0.1). Thus, there was no significant effect of
very-low- dose aspirin in our trial.
ARTICLES
Danish very-low-dose aspirin after carotid endarterectomy trial
Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
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