Stroke, Vol 19, 1285-1288, Copyright © 1988 by American Heart Association
F Fazekas, K Niederkorn, R Schmidt, H Offenbacher, S Horner, G Bertha and H Lechner
We studied 52 asymptomatic subjects using magnetic resonance imaging, and
we compared age-matched groups (51-70 years old) with and without white
matter lesions with respect to carotid ultrasonography, cerebral blood flow
(xenon-133 injection), and cerebrovascular risk factors. In the group with
white matter signal abnormalities, we noted a higher frequency of
extracranial carotid artery disease, a lower mean gray matter blood flow
(F1), and a significant reduction (p less than 0.05) in blood flow of the
slow-flowing (F2) compartment. Hypertension, diabetes mellitus, and cardiac
diseases (p less than 0.002) were found more often in this group. Our
results indicate that a higher incidence of changes known to be associated
with an increased risk for stroke exists in the presence of white matter
lesions in normal elderly individuals.
ARTICLES
White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors
Department of Neurology, University of Graz, Austria.
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