Stroke, Vol 19, 1345-1353, Copyright © 1988 by American Heart Association
G Boysen, J Nyboe, M Appleyard, PS Sorensen, J Boas, F Somnier, G Jensen and P Schnohr
Stroke incidence in Copenhagen, Denmark was recorded in a random population
sample of 19,327 persons invited for two health examinations with 5 years'
interval from 1976 to 1983. Stroke incidence increased exponentially with
age. After adjustment to the age and sex distribution of the Danish
population in 1980, the estimated incidence of first stroke was 1.41/1000
women and 2.48/1000 men; the total incidence was 1.94/1000 population. Risk
factor analysis was based on the initial examination of 13,088 persons
greater than 35 years old without previous stroke who responded to the
first invitation, in whom 295 first strokes were subsequently observed. We
used the regression model of Cox. However, our use of this model differs
from the somewhat automatic procedures normally used to develop prognostic
models. Evaluation of the causative effect of a particular risk factor
requires that the direction of mutual influences between the factor in
question and other risk factors is established/postulated. Among the 16
potential risk factors for stroke we examined, significant effects were
found for age, sex, household income, smoking habits, systolic blood
pressure, diabetes, plasma cholesterol concentration, ischemic heart
disease, and atrial fibrillation. No significant effect could be
demonstrated for a positive family history of stroke, years of school
education, marital status, alcohol consumption, daily use of tranquilizers,
body mass index, or postmenopausal hormone treatment.
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Stroke incidence and risk factors for stroke in Copenhagen, Denmark
Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
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