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Stroke. 1988;19:1482-1484

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Stroke, Vol 19, 1482-1484, Copyright © 1988 by American Heart Association

ARTICLES

Timing of autopsy-confirmed hemorrhagic infarction with reference to cardioembolic stroke

J Lodder, B Krijne-Kubat and PJ van der Lugt
Department of Neurology, University Hospital, Maastricht, The Netherlands.

We studied the temporal profile of hemorrhagic transformation in 34 cases with autopsy-confirmed hemorrhagic infarction who died within 15 days following a supratentorial brain infarct, provided they had undergone computed tomography. It appeared that within 4 days, at least 76% (95% confidence interval 39-100%) of 21 cardioembolic strokes had become hemorrhagic. We conclude that if anticoagulation is considered in cardioembolic stroke, such treatment should not be started sooner than at least 4 days after the onset of stroke, provided that computed tomography at that time shows no hemorrhagic infarction.


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