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Stroke, Vol 19, 266-268, Copyright © 1988 by American Heart Association

ARTICLES

Reversible osmotic opening of the blood-brain barrier in mice

WR Fredericks and SI Rapoport
Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.

Unilateral reversible osmotic opening of the blood-brain barrier can be produced in mice. Infusion of 1.8 molal arabinose in water at a rate of 0.64 ml/min for 30 seconds into the internal carotid artery consistently results in ipsilateral brain staining by intravascular Evans blue dye. Osmotic opening is concentration-dependent (threshold, 1.6 molal arabinose) and reversible within 4 hours. No long-term neurologic deficit occurs. These results suggest that reversible osmotic blood-brain barrier opening can be applied to disease models in mice.

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