Stroke, Vol 19, 423-430, Copyright © 1988 by American Heart Association
GS Tell, JR Crouse and CD Furberg
Although blood lipids and lipoproteins are strongly related to coronary
atherosclerosis, their association with cerebrovascular atherosclerosis is
less clear. A review of more than 20 publications in which a relation was
sought between plasma lipid and lipoprotein concentrations and
cerebrovascular atherosclerosis leads to the general conclusion that such a
relation exists and that it is stronger in older than in younger
individuals. A relation was found between blood lipids and/or lipoproteins
and the extent and/or severity of cerebrovascular atherosclerosis in all
but three of 26 reviewed studies. However, the specific nature of the
relation is obscure because the various studies cannot easily be compared
with one another. Interstudy variations in lipoprotein fraction analyzed,
methodology for the analysis of lipids and lipoproteins, arterial segment
examined, population sampled, control selection in case-control studies,
statistical analytic approach taken, and methodology for the assessment of
arterial disease preclude pooled analyses. There is a clear need for
further evaluation of this relation using standardized and up-to-date
methodologies both for analyses of lipids and lipoproteins and for
assessment of cerebrovascular disease in symptom-free volunteers as well as
in symptomatic patients.
ARTICLES
Relation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. A review
Center for Prevention Research and Biometry, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
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