Stroke, Vol 19, 480-485, Copyright © 1988 by American Heart Association
K Abe, S Yuki and K Kogure
Regional changes in the amount of free fatty acids, polyphosphoinositides,
and water content in the cerebral cortex were examined using a middle
cerebral artery occlusion model of rats. The amount of various free fatty
acids increased as polyphosphoinositides decreased during 3 and 6 hours of
ischemia in the occluded middle cerebral artery territory. After 3 hours of
reperfusion following 3 hours of ischemia, free fatty acids partially
recovered while polyphosphoinositides did not. Water content increased
significantly after 3 and 6 hours of ischemia, and a further increase was
found after 3 hours of reperfusion following 3 hours of ischemia. The
change of polyenoic fatty acids in this occluded middle cerebral artery
territory was much smaller than that in the case of decapitation ischemia,
although the amounts of polyphosphoinositides and monoenoic and saturated
fatty acids showed almost identical changes in both cases, probably because
polyenoic fatty acids may be washed out and/or peroxidatively consumed in
the middle cerebral artery occlusion model due to its residual blood flow.
Changes in the area surrounding the occluded middle cerebral artery
territory were similar to the above results, although less dramatic.
However, there was no change in free fatty acids, polyphosphoinositides,
and water content in the contralateral cortex. A novel free radical
scavenger (MCI-186), which prevents both nonenzymatic peroxidation and
lipoxygenase activity in vitro, markedly attenuated the ischemic and
postischemic brain swelling. These results suggest that free radical
mechanisms may be involved in ischemic and postischemic brain edema.
ARTICLES
Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
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